High-throughput biochemical profiling reveals Cas9 off-target binding and unbinding heterogeneity

Department of Genetics, Stanford University, Stanford CA Department of Biochemistry, Stanford University, Stanford CA Department of Chemical & Systems Biology, Stanford University, Stanford CA Department of Chemistry, University of California, Berkeley, CA. Biomedical Informatics Training Program, Stanford University, Stanford CA. Department of Molecular and Cell Biology, Howard Hughes Medical Institute University of California, Berkeley, CA. Innovative Genomics Initiative, University of California, Berkeley, CA. Lawrence Berkeley National Laboratory, Berkeley, CA Department of Applied Physics, Stanford University, Stanford CA.